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February 19, 2012

6 Oct 1998 use in assays, for treatment of cocaine overdose and detoxification. .. BSA or keyhole limpet hemocyanin (KLH) (120 mg dissolved in 6 ml

March 21, 2012

The immunotoxicity of prenatal cocaine exposure was investigated using serum IgM), delayed-type hypersensitivity response to KLH, and lymphocyte effects; Cell Division/drug effects; Cocaine/administration & dosage

La molécule de cocaïne, en elle-même trop petite pour être immunogène, a été la protéine keyhole limpet hemocyanin (KLH) utilisée comme porteur pour . Treatment of severe colchicine overdose with colchicine-specific Fab fragments.

Adding more recent authority to this distinction is In the Int. of K.L.H., 281 Ga. .. But in another case the Court held that “it is a fair inference that use of cocaine by a .. App. 325 (2004), where the mother accidentally overdosed her child on

1 Apr 2003 use in assays, for treatment of cocaine overdose and detoxification. .. of BSA or keyhole limpet hemocyanin (KLH)(120 mg dissolved in 6 ml

February 27, 2012

Although cocaine overdose is not common, it can occur and can be fatal. Because limpet jenna jameson porn hemocyanin (KLH) or with the anti- cocaine mAb

4 Jan 2000 use in assays, for treatment of cocaine overdose and detoxification. .. of BSA or keyhole limpet hemocyanin (KLH)(120 mg dissolved in 6 ml

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These effects of OXY(Gly)4-KLH on drug disposition were comparable to those of . to increase morphine tolerance in respiratory depression and lethal overdose .. Orexin-1 receptor mediation of cocaine-seeking in male and female rats

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There has been a similar lack of success in the treatment of cocaine addition, and antibody was identified by screening GNC-(coupled to KLH) vaccinated mice reinstatement and cocaine overdose prevention (Carrera et al., Pharmacol.

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November 9, 2011

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Antibody 7A1 hydrolyzes cocaine to produce nonpsychoactive metabolites ecgonine (FDA) are available for cocaine craving, addiction, and overdose. to the carrier protein keyhole limpet hemocyanin (KLH) (Matsushita et al., 2001).

3 Jul 2011 response) to a generic carrier protein called keyhole limpet hemocyanin or KLH, . A Receptor in the Brain Makes Cocaine Relapse More.

September 30, 2011

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January 6, 2012

This invention further provides a method for treating cocaine overdose in a subject .. Thus, BALB/c mice (6) may be immunized with ligand bound to KLH ( 100

haemocyanin (KLH) to enable antibody production. appropriate protein carrier such as KLH, BSA and treatment of cocaine overdose.

The method of claim 10, wherein the addictive drug is cocaine. was identified by screening GNC- (coupled to KLH) vaccinated mice of cocaine reinstatement and cocaine overdose prevention (Carrera et al., Pharmacol.

Abstract Cocaine and opioid dependence are common, complex disorders 2006a), and chromosome 14q showed suggestive linkage for OD in an .. KLH. L. 5. G. 0.38. 31. 2 .0. 0.04. 0.57. 46. 2.0. 0.04. 0.49. 77. 2.9. 0.00. 4 rs13. 813. 55. 4

January 20, 2012

reduce cocaine overdose in the subject. .. Thus, BALB/c mice (6) may be immunized with ligand bound to KLH (100 .mu.g) in adjuvant,

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Design of Cocaethylene and Cocaine conjugates to produce highly selective tetanus toxoid or keyhole limpet hemocyanin according to different by the lack of effective pharmacotherapies for treating cocaine overdose.

antibodies: Digitalis and cocaine toxicity therapies. W.J. Balla,∗, S. Paulaa, to detoxify patients suffer- ing from overdoses occurring during therapeutic treat- benzoylecgonine-KLH conjugates suspended in CFA, followed by weekly or

March 22, 2012

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The predominant drugs used today are cocaine, heroin and In the absence of a specific antagonist, the treatment for cocaine overdose is to sedate of BSA or keyhole limpet hemocyanin (KLH)(120 mg dissolved in 6 ml of

Cocaine can be degraded by hydrolysis of the benzoyl ester group to yield inactive Km and Kcat parameters are effective in animal models of cocaine overdose . mAb GNC92h3, and active immunization with the new conjugate GND-KLH.

February 5, 2012

These effects of OXY(Gly)4-KLH on drug disposition were comparable to those of . by respiratory depression and the possibility for fatal overdose in drug abusers . .. Based on the known sex differences in cocaine addiction, in the current

psychostimulant (i.e., cocaine) with the longer-acting-depressant. (opiate substance) may highly increase the risk of seizure, overdose

Cocaine increases actin cycling: effects in the reinstatement model of drug seeking. . that offers realistic options for therapy of cocaine overdose and abuse . . that active immunization with the nicotine immunoconjugate IP18-KLH attenuates

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August 9, 2011

In many studies it has been shown to be more addictive than cocaine and heroin. the nicotine molecule to a hapten such as Keyhole limpet hemocyanin or a safe It is unlikely that a person would overdose on nicotine through smoking

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killed by an overdose of pentobarbital sodium at the end of each experiment .. [ 13] Tai, M. H.; Wang, L. L.; Wu, K. L. H.; Chan, J. Y. H. Increased superoxide anion in J. Acute or repeated cocaine administration generates reactive oxygen

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March 23, 2012

Email: Histórico. cocaine self-administration(3164). Origens

He ordered Fizzuoglio to prepare the lines of cocaine and ordered both When she told the deputies she had taken cocaine, they believed she was overdosing and sent her to the hospital in an ambulance. . Report Date: 07/10/08 KLH

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The effects of immunization with the second-generation cocaine immunoconjugate GND-keyhole limpet hemocyanin (KLH) or with the anti- cocaine mAb

March 23, 2012

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This study presents a characterization of cocaine/antibody clinical potential for development as a treatment of cocaine overdose and addiction. . of the benzoylecgonine−KLH conjugate would be an acceptable mimic of the

After i.p. administration of cocaine small middle dotHCl (15 mg/kg), rats were Active immunization with GND-KLH produced a 76% decrease in the dosage; Antibodies, Monoclonal/immunology; Cocaine/immunology*

November 22, 2011

Pubget: authors:M Rocio A Carrera - The illicit use of cocaine continues in epidemic proportions and treatment for cocaine overdose remains elusive. ( KLH) in preventing cocaine self-administration reinstatement was assessed in rats.

Records 61 - 90 Immunopharmacotherapeutic manifolds and modulation of cocaine overdose. to those of its engineered formats in a mouse overdose model. . coupled to several carrier proteins such as KLH, HBsAg and P64k (recombinant

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September 4, 2011

following an acute cocaine overdose, and these seizures can be treated with intravenous precipitation, ion exchange and KLH affinity chromatographies.

[0006] Drug addiction, drug abuse, and drug overdose are problems which afflict many . the effects of a drug of abuse on a patient or in treating a drug overdose. [0111] The amount of KLH needed was calculated as follows: It was

Cocaine-induced lethality(7988). Origens. SciELO - Scientific

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March 19, 2012

Catalytic Antibodies from Anti-cocaine Vaccines: This new study explains to be stable and long-lived, and conjugated it to keyhole limpet hemocyanin (KLH). be useful in animal studies or in cases of cocaine overdose/toxcicity in humans.

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KLH), and assessed whether their concurrent administration would produce additive .. potential of CocE mutants for the treatment of cocaine overdose and

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August 26, 2011

171 Epidemiological Report of Overdose with Psychotropic Drugs . 231 A COCAINE BODY PACKER CASE REPORT: CLINICAL AND FORENSIC . 339 KEYHOLE LIMPET HEMOCYANIN (KLH) ADMINISTERED BY THE

Several procedures that reflect the behavioral effects of cocaine in rodents . with GNC-KLH in an animal model of cocaine self-administration relapse in the rat. . TO TREAT PHENCYCLIDINE ABUSE AND OVERDOSE IN A RAT MODEL

Cocaine access to brain tissue and associated cocaine-induced behaviors are succinyl norcocaine conjugated to keyhole limpet hemocyanin, was from massive seizures following a normally lethal cocaine overdose and

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April 7, 2012

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Other groups implemented similar cocaine-KLH haptens in the efforts to blunt In a model of cocaine overdose, mAb15A10 protected rats from cocaine-induced

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cocaine). The sensitivities of antibodies to (R)- and (R,S)-Mtd were about 1 and 2 ng/ml, respectively. Selective nin from keyhole limpets (KLH), PBS, 0.05% Tween 20, pH. 7.4 (PBS-T) were .. matography and serotherapy of Mtd overdoses.

January 17, 2012

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Cocaine is a highly addictive drug, and despite intensive efforts, effective to the carrier protein KLH, reduced the psychoactive effects of cocaine and for clinical applications, particularly for cases of cocaine overdose.

8 Dec 2009 failure, surgery, cancer, gastroenteritis, and cocaine overdose (Laurino, J.P. et 5114923) conjugated to KLH by standard techniques.

of active immunizations against cocaine and nicotine show the potential benefit of this (Fab) to cure digoxin overdose and cardiac toxicity.20 coupled to keyhole limpet hemocyanin (KLH) in rats produced significant

May 7, 2012

Anti-cocaine vaccine degree of sedation and respiratory depression, the slowing down of breathing that makes heroin overdoses so dangerous. . 10 shows the synthesis of norbuprenorphine KLH immunogen (33) of the present invention;

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Changes in brain and liver cytochrome P450 after multiple cocaine administration, Plasma concentrations before and after a deliberate overdose .. The KLH-assay as alternative to the PFC-assay: A comparative study with

November 10, 2011

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Abbreviations: KLH, keyhole limpet hemocyanin; mAb, monoclonal antibody; Ig, .. is for cases of cocaine overdose in an emergency room or paramedic setting.

In the absence of a specific antagonist, the treatment for cocaine overdose is to include bovine serum albumin, keyhole limpet hemocyanin, cholera toxin B,

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October 23, 2011

In preferred embodiments, it provides for anti-cocaine vaccines and their use to containing cocaine conjugated to KLH and the mucosal adjuvant, of the immunized mice succumbed to cocaine overdose at either LD50 or

Human clinical trials are under way for the cocaine and nicotine vaccines. to a generic carrier protein called keyhole limpet hemocyanin or KLH, and mixed it with . Heroin depresses breathing, thus, overdose can be fatal.

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January 7, 2012

28 Jul 2011 exemplified by morphine; and WO 96/30049, exemplified by cocaine). . The device can be designed so as to avoid overdosing such as by restricting .. The conjugate to KLH was used to immunize mice and to produce

from the group consisting of desipramine ethylcarbonyl-KLH-nortriptyline

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Antibody-based treatments have been used for many years for drug overdose detoxica- hole limpet hemocyanin (KLH) according to the method outlined later .

September 4, 2011

Compared with controls, animals immunized with GNC-KLH did not Cocaine/ administration & dosage; Cocaine/analogs & derivatives*

drug overdose scenario as well as during the critical time points in the (KLH) elicited elevated antibody titers with high affinity for cocaine

Cocaine addiction persists as a significant public health problem for which no to the treatment of cocaine addiction and cocaine overdose. such as keyhole limpet hemocyanin or recombinant cholera B toxin (rCTB).

tive pharmacotherapies for treating cocaine overdose. ments for cocaine overdose and addiction. tons), or keyhole limpet hemocyanin (KLH: Imject Mari -

August 7, 2011

Human clinical trials are under way for the cocaine and nicotine vaccines. a generic carrier protein called keyhole limpet hemocyanin or KLH, and mixed it with increase the risks of addiction, abuse and serious overdose.

nucleus accumbens of cocaine-related deaths22 and fatal cocaine overdose . Active immunization with a stable cocaine-KLH conjugate lowered cocaine

Human clinical trials for the cocaine and nicotine vaccines are to a generic carrier protein (called keyhole limpet hemocyanin or KLH) and

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In 2007 Winehouse was admitted to the hospital after overdosing on a We don't have a good drug for cocaine addiction, but we have drugs for .. to a generic carrier protein called keyhole limpet hemocyanin or KLH, and

It is easily overdosed, with an increase of heroin-related deaths being . Human clinical trials are under way for the cocaine and nicotine vaccines. to a generic carrier protein called keyhole limpet hemocyanin or KLH, and

Immunization of rats with a high dose of anti-cocaine vaccine or passive limpet hemocyanin (KLH) in rats produced significant anti-METH antibody In the acute overdose model, the mAb was administered 30 min after the

February 24, 2012

The data from cocaine and nicotine vaccine trials suggest that many patients .. polyclonal antibodies generated by KLH-S-Meth or OMPC-S-Meth (Orson, therefore it is susceptible to abuse and overdose, including adverse

Cocaine and nicotine provide an example of this contrast, in which the former is most . group was attached to keyhole limpet hemocyanin (KLH). Such monoclonals could presumably be useful for treatment of overdoses,

was also generated using the GNC-KLH immunoconjugate. 7. GNC92H2 binds clinical applications, particularly for cases of cocaine overdose. A lower K d

Quando conjugada com o KLH houve uma diminuição de 80% dos níveis Dose-response effect of fetal cocaine exposure on newborn neurologic function. . A overdose acontece por superdosagem, ou seja, o usuário utiliza-se de uma

September 29, 2011

linked to the carrier protein KLH led to the identification of several mAbs .. antibody GNC92H2 as an immunotherapy for cocaine overdose.

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approach can stop the drug-seeking behavior of cocaine- addicted rats and protect them against an overdose that was lethal for controls (12). hydroxyphosphinate Hb-KLH were prepared by adding 9 μmol of hapten to 3 mg of KLH in 2 ml of

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comparable to those of nicotine or cocaine vaccines that are in KLH immunogen as a potential treatment option for OXY abuse or increase in the incidence of emergency department visits and fatal opioid overdose.

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September 8, 2011

Cocaine abuse and addiction are serious problems, and overdose is severe in mice using a transition state analog attached to keyhole limpet hemocyanin.

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Psychoactive substances such as cocaine, nicotine, alcohol, and . making this approach particularly relevant in a drug overdose scenario as well as (KLH) elicited elevated antibody titers with high affinity for cocaine (Kd

January 7, 2012

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This invention further provides a method for treating cocaine overdose in a .. Thus, BALB/c mice (6) may be immunized with ligand bound to KLH (100 μg) in

LD50 cocaine dose (93 mg/kg, i.p.), and the timeline of overdose symptoms .. KLH immunizations and hybridoma production with the most

22 Jul 2011 an immune response) to a generic carrier protein called keyhole limpet hemocyanin or KLH, . Vaccine Could Eliminate Cocaine Addiction

March 27, 2012

These effects of OXY(Gly)4-KLH on drug disposition were comparable to those of nicotine or cocaine vaccines that are in clinical trials as addiction treatments. .. on reducing relapse among a sample of patients in treatment for OD. Patients

Ettinger produced a vaccine in 1997 by coupling cocaine to KLH through a .. antibody GNC92H2 as an immunotherapy for cocaine overdose.

haemocyanin (KLH) to enable antibody production. appropriate protein carrier such as KLH, BSA and adjuvants such as treatment of cocaine overdose.

Epidemiologically, the pyschostimulants such as cocaine and death index related to the toxic effects induced by the overdose of such substances. .. Some high molecular weight proteins such as BSA and KLH have been

May 8, 2012

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in animals immunized with cocaine-KLH as compared to saline controls [63]. . in cases of overdose, improvements upon presently available. mAbs would be

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April 26, 2012

Cocaine is a powerful and addictive stimulant whose abuse remains a system; KLH, keyhole limpet hemocyanin; CDR, complementarity determining region; TSA, of blocking cocaine toxicity in an overdose model.9 Another protein- based

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See the article "A Cocaine Hydrolase Engineered from Human mAb GNC92H2 is capable of blocking cocaine toxicity in an overdose model 9. Figure 1) linked to the carrier protein KLH led to the identification of several

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February 20, 2012

drug overdose experimentally (Brunn, Keyler, Pond, &. Pentel, 1992; Valentine body effect by increasing the cocaine dose, or switching to the abuse of a different Rats immunized with either CMUNic-KLH (n = 10) or. KLH alone ( controls, n

Cocaine-KLH conjugate was prepared and administered in two formulations. Brain/metabolism; Cocaine/administration & dosage; Cocaine/antagonists &

cocaine(98). Origens. PubMed CentralSciELO - Scientific

The initial rate constants for cocaine benzoyl thioester hydrolysis and many years for drug overdose detoxication, including digoxin (Smith et al., This mixture was then added to a solution of KLH (10 mg in 500 μl of H2O)

November 4, 2011

Bagasra et al. investigated using cocaine-KLH vaccination as a means to .. to prevent death (for example, when a person presents with a drug overdose).

Synthesis and inhibition of binding to the cocaine receptor,” J. Med. .. by the above criteria could be suitable for the treatment of acute overdose. . bovine serum ovalbumin, keyhole limpet hemocyanin or thyroglobulin.

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He ordered Fizzuoglio to prepare the lines of cocaine and ordered both Fizzuoglio When she told the deputies she had taken cocaine, they believed she was overdosing and sent her to the . Report Date: 07/10/08 KLH

January 9, 2012

phencyclidine overdose [2]. the effects of cocaine with cocaine-KLH conjugates have met 2.2 Novel cocaine hapten-KLH conjugates

It is unlikely that a person would overdose on nicotine through

gency setting in the event of drug overdose and in a long-term rehabilitation program. hapten GNC coupled to keyhole limpet hemocyanin (KLH). (Fig. 1).

Evaluation of Atomoxetine for Cocaine Dependence: A Pilot Trial Specific Idiotype/KLH) and GM-CSF in Subjects Who Demonstrated Development of Esterases for the Treatment of Cocaine Overdose and Abuse

November 9, 2011

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Early clinical trials with anticocaine and antinicotine vaccines have shown from acute drug toxicity or overdose (a clinical problem for all drugs except nicotine). .. vaccination (cocaine coupled to keyhole limpet hemocyanin), extinction and

the pursuit of mAb therapeutics for nicotine and cocaine has advanced hapten RCA was coupled to BSA or KLH carrier proteins using EDC and

January 6, 2012

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Is the self-report of recent cocaine or methamphetamine use reliable in illicit stimulant drug users who present to . Hyperthermia in psychostimulant overdose.

for nicotine and cocaine has advanced into clinical trials 1, 2, 11. hapten RCA was coupled to BSA or KLH carrier proteins using EDC and

Field of Invention The invention relates to methods for treating cocaine abuse. to be therapeutically employable for treating cocaine overdose and/or cocaine .. After 20 hours at 22° C. (range 15-30° C.) the solution was added to KLH, (20

January 12, 2012

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CONCLUSIONS: Cocaine-related overdoses in nonurban areas should be a . conjugated to the carrier proteins BSA or KLH produced high-titer antibodies to

April 23, 2012

6 Feb 2001 treating cocaine overdose in a subject which comprises an amount of .. Thus, BALB/c mice (6) may be immunized with ligand bound to KLH

at 10 to 40 min were 4 to 6-fold higher in the CMUNic-KLH rats the self- administration of heroin but not of cocaine, a result .. of treating drug overdose. In this

anti-craving medication for addiction to cocaine, the .. GND-keyhole limpet hemocyanin (KLH) or treated diminished consequences of cocaine overdose in

Cocaine;; Drug overdose;; Immunopharmacotherapy;; Vaccine;; Passive immunization; . GNC92H2 was previously identified as the mAb clone from GNC-KLH

September 18, 2011

Antibody 7A1 hydrolyzes cocaine to produce nonpsychoactive metabolites diction, and overdose. age to the carrier protein keyhole limpet hemocyanin

Records 1 - 30 Immunopharmacotherapeutic manifolds and modulation of cocaine overdose. compared to those of its engineered formats in a mouse overdose model. .. on a d-mannitol-keyhole limpet hemocyanin (KLH)-Sepharose CL-6B


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