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DISCUSSION Rebound hypertension has been reported to occur following abrupt withdrawal of clonidine,1~-1~ methyldo- pa,17 andpropranolol therapy.18 The
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Clonidine is a direct-acting adrenergic agonist prescribed historically as an Rebound hypertension can be avoided by slowly withdrawing treatment.
These agents, too, are used in treating the rebound hypertension caused by α- methyldopa or clonidine withdrawal. CNS sympathetic inhibitors such as
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The clonidine should first be slowly tappered down and not withdrawn suddenly due to the risk of rebound hypertension and tics. Once the clonidine has been
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Clonidine is better avoided because of the risk of rebound hypertension if doses are missed for any reason. It should never be prescribed with a. B-blocker.
Antihypertensive compounds such as clonidine have been widely used to treat mouth dryness) and because of the rebound hypertensive effect seen after
Clonidine withdrawal mechanism and frequency of rebound hypertension. A reply to the letters of Dr. McMahon (1979) and Drs Whitsett & Chrysant (1979)
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