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November 2, 2011

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Context Recent reports of serious adverse events with rosiglitazone use myocardial infarction, heart failure, and cardiovascular mortality.

Nissen SE, Wolski K. Rosiglitazone revisited: an updated meta-analysis of risk for myocardial infarction and cardiovascular mortality. Arch Intern Med. 2010

Diamond GA, Bax L, Kaul S. Uncertain effects of rosiglitazone on the risk for myocardial infarction and cardiovascular death. Ann Intern Med.

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February 26, 2012

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October 22, 2011

There is no evidence to suggest that use of Avandia increases the risk for cardiovascular mortality and morbidity in patients with type 2 diabetes

The risk of heart failure and death for older diabetics appears greater to use Actos, because Avandia has cardiovascular risks associated with

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September 9, 2011

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Context Controversy regarding the effects of rosiglitazone therapy on myocardial infarction (MI) and cardiovascular (CV) mortality persists 3

March 30, 2012

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April 24, 2012

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October 16, 2011

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August 8, 2011

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GlaxoSmithKline's Avandia is prescribed for 1 million Americans for type 2 known to increase the risk of heart attack by 43% and cardiovascular death by 64 %.

"Effect of Rosiglitazone [Avandia] on the Risk of Myocardial Infarction and Death from Cardiovascular Causes" is a retrospective study investigating signs of

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January 16, 2012

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September 10, 2011

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April 11, 2012

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November 18, 2011

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November 11, 2011

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March 15, 2012

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May 3, 2012

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October 28, 2011

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September 20, 2011

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January 20, 2012

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Steven E. Nissen, M.D., and Kathy Wolski, M.P.H., “Effect of Rosiglitazone on the Risk of Myocardial Infarction and Death from Cardiovascular

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Two meta-analyses found higher risks of myocardial infarction with rosiglitazone than with control therapy; the risk of cardiovascular death was not different.

The hypoglycaemic thiazolidinedione rosiglitazone is used clinically in the rosiglitazone does not increase cardiovascular mortality/morbidity

September 12, 2011

The article 'Effect of Rosiglitazone on the Risk of Myocardial Infarction and Death from Cardiovascular Causes' (10.1056/NEJMoa072761) was

Commentary on February 19 New York Times article on Avandia of death or hospitalization for cardiovascular disease in patients taking Avandia as compared

The US FDA did not approve muraglitazar, a dual alpha/gamma agonist, because of the increased risk of cardiovascular death and mortality. Both rosiglitazone

Nissen SE, Wolski K: Rosiglitazone revisited: an updated meta-analysis of risk for myocardial infarction and cardiovascular mortality.

February 12, 2012

Wolski K. Effect of Rosiglitazone on the Risk of Myocardial Infarction and Death from Cardiovascular Causes. New England Journal of Medicine

showed that rosiglitazone (Avandia) in- creased the risk of cardiovascular events and death. Rosiglitazone maker GlaxoSmithKline presented a review of clinical

Despite the many things you have heard about Avandia, back in July . no increased cardiovascular mortality, no increased cardiovascular

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December 12, 2011

A prospective clinical trial of the diabetes drug Avandia has failed to clear the rates or cardiovascular mortality compared with those taking other diabetes drugs . Avandia certainly did not improve cardiovascular outcomes,

A 19% increase in all cause mortality and a 43% increase in cardiovascular mortality cannot be excluded.” Avandia (rosiglitazone) is the poster

This study acquainted us with an evidence that short-term use of rosiglitazone may increase the risk of Myocardial Infarction and cardiovascular death. While the

Thiazolidinediones (Pioglitazone/Actos, Rosiglitazone/Avandia) . HR was 0·84 ( 0·59—1·18) for cardiovascular death, 1·14 (0·80—1·63) for myocardial

February 12, 2012

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Patients taking Avandia are at increased risk of heart attack, cardiovascular death , primary pulmonary hypertension (PPH), heart valve disease and heart valve

Several studies have linked the anti-diabetes drug rosiglitazone, cardiovascular mortality and morbidity. Rosiglitazone belongs to the class of

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The conclusions of this analysis of previous studies of rosiglitazone (brand name, with increased risk of heart attack and death from cardiovascular causes.

2- Nissen SE et al. Rosiglitazone revisited. An updated meta analysis of risk for myocardial infarction and cardiovascular mortality. Arch Intern

Avandia has been associated with serious cardiovascular risks and diabetes patients; heart attack risk is increased by 43% and cardiac-related death by 64%.

December 13, 2011

Risk of cardiovascular death with rosiglitazone was not statistically different from comparators (Odds Ratio 1.64; 95% CI 0.98 to 2.74). In absolute numbers

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Tips from Other Journals. Rosiglitazone Is Associated with Increased Cardiovascular Mortality. Am Fam Physician. 2008 Mar 15;77(6):844-849.

May 19, 2012

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tion about the CV-mortality difference between Avandia and its control group using the RR approach. As a result, they deleted 19 studies (with no events) from

It was reported in the New England Journal of Medicine that Avandia could increase the risk of heart attack up to 43% and the risk of cardiovascular death by as

Rosiglitazone is widely used to treat patients with type 2 diabetes mellitus, but its effect on cardiovascular morbidity and mortality has not been

March 4, 2012

Thus far in the trial, no statistically significant evidence of an increase in death from cardiovascular causes associated with rosiglitazone has been identified.

effects of rosiglitazone for MI, heart failure, and cardiovascular mortality are shown in FIGURE 2. MI and Heart Failure. Our pooled data from 4 long-term trials

Some studies, but not all, also link Avandia to cardiovascular risks such as heart attack and death. (Avandia's label describes research linking the drug to risk of

There was no evidence of any increase in death from either cardiovascular causes or all causes. Rosiglitazone was associated with an

July 30, 2011

Rosiglitazone is widely used to treat patients with type 2 diabetes mellitus, but its effect on cardiovascular morbidity and mortality has not been determined.

A large clinical trial of Avandia, sponsored by its maker, was to compare the risk of heart attacks, stroke and cardiovascular death in diabetes

GSK stands firmly behind the safety of Avandia when used abilities to reduce the complications of diabetes-such as cardiovascular death."

Effect of Rosiglitazone on the Risk of Myocardial. Infarction and Death from Cardiovascular Causes. Steven E. Nissen, M.D., and. Kathy Wolski, M.P.H.. N Engl J

December 4, 2011

Many studies have associated Actos and Bladder Cancer, Rosiglitazone, using cardiovascular death and deaths. Rosiglitazone is a member of

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Two meta-analyses have examined the association between rosiglitazone and cardiovascular death. The first included 14376 patients from many small studies


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