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Assignee Name:BIOCON LIMITED Inventor Name:SRINATH SUMITRA,MATHEW JOY,UJIRE SANDHYA,SRIDHARAN MADHAVAN
Prolonged inhibition of cholesterol synthesis explains the efficacy of atorvastatin. Rossitza P. Naoumova," Stuart Dum,* Loukianos Rallidis," Omar Abu-Muhana,*
Li, J. J., Johnson, D. S., Sliskovic, D. R. and Roth, B. D. (2004) Atorvastatin Calcium (Lipitor®), in Contemporary Drug Synthesis, John Wiley
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Relative potencies of statins in reducing cholesterol synthesis and sterol synthesis, whereas atorvastatin in stimulating the conversion of linoleic acid.
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Title: Synthesis of Some Impurities and/or Degradation Products of Atorvastatin. Creators: Stach, Jan. Havlíček, Jaroslav. Plaček, Lukáš
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The present invention relates to oxidative degradation products of atorvastatin calcium and the process of the preparation thereof. The present
Efficacy and safety of a new cholesterol synthesis inhibitor, atorvastatin, in comparison with simvastatin and pravastatin, in subjects with hypercholesterolemia.
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2003). Interestingly, atorvastatin at proangiogenic concentrations (0.01 to 0.1 [mu ]M) did not affect IL-8 synthesis in HUVECs. On the contrary, higher, micromolar
Atorvastatin inhibits a rate-determining enzyme located in hepatic tissue used in cholesterol synthesis, which lowers the amount of cholesterol
The prodrug of atorvastatin (Atorvastatin ethyl ester) was synthesized. In-vitro permeation study was performed using a modified Franz cell and the stratum
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ATORVASTATIN is an HMG-CoA reductase inhibitors decrease cholesterol synthesis and theoretically might blunt adrenal and/or gonadal steroid production .
Atorvastatin (40%); Simvastatin (30%); Other Statins (10-20%) . inhibit HMG- CoA reductase, the rate-limiting enzyme in cholesterol synthesis.
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Process for preparing C5 products and their use for Atorvastatin synthesis. European Patent Application EP1705175. Kind Code: A1. Abstract:
Synthesis Of Lipitor Statin Drugs. A small worm that is used as a organism in genetics studies, Caenorhabditis elegans, Synthroid and lipitor
a higher rate of cholesterol synthesis, which was more susceptible to pharmacological inhibition. The more marked cholesterol lowering effect of atorvastatin 80
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Radl et al., "An improved synthesis of 1,1-dimethylethyl-6-cyanomethyl-2,2- dimethyl-1,3-dioxane-4-acetate, a key intermediate for atorvastatin synthesis",
Atorvastatin inhibits a rate-determining enzyme located in hepatic tissue used in cholesterol synthesis, which lowers the amount of cholesterol produced.
Synthesis of deuterium-labeled atorvastatin and its metabolites for use as internal standards in a LC/MS/MS method developed for quantitation
A statin, (C33H34FN2O5)2Ca · 3H2O, that blocks the body's synthesis of cholesterol and is administered Log in or sign up to show 'atorvastatin' some love.
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Synthesis of Some Impurities and/or Degradation Products of Atorvastatin (2008). Stach, Jan,; Havlíček, Jaroslav,; Plaček, Lukáš,; Rádl, Stanislav. Abstract
The present invention discusses a novel process for the synthesis of [R-(R*,R*)]-2 -(4-fluorophenyl)-B
A process for the preparation of atorvastatin in an amorphous form, which comprises: a) providing a solution of atorvastatin in one or more solvents of a first type
Objective To investigate the effects of atorvastatin on the proliferation and collagen synthesis in cultured rat cardiac fibroblasts (CFs). Methods CFs were
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[0007] There is thus a need to optimise this rate limiting step in the preparation of atorvastatin. Statements of Invention. [0008] According to the
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The invention relates to a new process for the synthesis of amorphous atorvastatin calcium, which consists of dissolving the salt of the formula
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Plasma mevalonic acid, an index of cholesterol synthesis in vivo, and Patients on atorvastatin were subdivided according to whether their reduction in LDL
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Atorvastatin Inhibits T Cell Activation through 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase without Decreasing Cholesterol Synthesis1
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Atorvastatin lowers plasma cholesterol and lipoprotein levels by inhibiting HMG‐ CoA reductase and cholesterol synthesis in the liver and by
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American Journal of Cardiology, Volume 104, Issue 12, Pages 1618-1623, 15 December 2009, Authors:M. Teresa Santos, PhD; M. Paz Fuset,
Atorvastatin. Original diagram from PharmGKB: Synthesized version: Results and Analysis: Proteins. Gold standard: [abcb1, abcc2, cyp2c, cyp2c19, cyp2c8,
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Preparation of Physical Mixture: Physical mixtures of atorvastatin calcium at three different mass ratios (1:1, 1:2 and. 1:3) were prepared in a glass mortar by
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PREPARATION OF NON-CRYSTALLINE ATORVASTATIN CALCIUM. 20/DELNP /2005 A (20/DELNP/2005). Filed on 2005-01-03. Publication
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Title: An efficient synthesis of N3,4-diphenyl-5-(4-fluorophenyl)-2-isopropyl-1H-3- pyrrolecarboxamide, a key intermediate for atorvastatin synthesis. Authors
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Atorvastatin lowers plasma cholesterol and lipoprotein levels by inhibiting HMG- CoA reductase and cholesterol synthesis in the liver and by increasing the
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Figure 2 The effect of patient plasma collected before and after therapy with atorvastatin on vascular endothelial growth factor (VEGF) synthesis by human
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An improved synthesis of 1,1-dimethylethyl 6-cyanomethyl-2,2-dimethyl-1,3- dioxane-4-acetate, a key intermediate for atorvastatin synthesis
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atorvastatin /ator·va·stat·in/ (ah-tor″vah-stat´in) an antihyperlipidemic agent that acts by inhibiting cholesterol synthesis, used as the calcium salt in the treatment
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Title, Comparison of the effects of maximal dose atorvastatin and rosuvastatin therapy on cholesterol synthesis and absorption markers. Publication Type
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Atorvastatin inhibits cholesterol synthesis via the mevalonate pathway by inhibiting 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase. HMG- CoA
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Atorvastatin belongs to the category of statins, which inhibits 3-hydroxy-3- methylglutaryl- coenzyme A (HMG-CoA) reductase. Synthesis of mevalonic acid is
The statins inhibit HMG-CoA reductase, which catalyzes the rate-limiting step in hepatic cholesterol synthesis. Atorvastatin was launched by the Warner Lambert
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It is an integral component in the synthesis of hormones, can also be found in cell walls of animals and humans. Synthetic Statins: Atorvastatin (Lipitor),
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The present invention provides novel forms of atorvastatin designated Forms VI, VIII, IX, X, XI and XII and novel processes for their preparation as well as
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technologies further for the chemical synthesis of fuels, chemicals, and materi- als. As illustrated in the example of levetiracetam, atorvastatin, and pregabalin,
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PREPARATION AND SOLID STATE CHARACTERIZATION OF. ATORVASTATIN NANOSUSPENSIONS FOR ENHANCED. SOLUBILITY AND DISSOLUTION
These enzymes participate in the oxidation of atorvastatin, giving rise to the synthesis of two active metabolites, 2-hydroxyatorvastatin and 4- hydroxyatorvastatin
An enzyme-based process operated by Lonza for the production of the major chiral building block for Pfizer's Lipitor, the world's best selling
atorvastatin synthesis. Pramod. S. Pandey* and T. Srinivasa Rao. Department of Chemistry, Indian Institute of Technology, Delhi, Hauz Khas, New Delhi-110016
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The aim of the present study was to investigate possible influence of two lipophilic statins (simvastatin and atorvastatin) on cholesterol synthesis in selected parts
By blocking cholesterol synthesis, Lipitor reduces the risk of heart disease and/or stroke. When response to diet and other non-drug measures alone are
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Biocatalytic synthesis of atorvastatin intermediates. Author. Patel, J. M.. Journal title. JOURNAL OF MOLECULAR CATALYSIS B ENZYMATIC. Bibliographic
This study was designed to investigate the ef- fect of atorvastatin on TSP-1 synthesis in thrombin-stimulated hu- man umbilical vein endothelial cells ( HUVECs),
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